Research Areas


Basically anything in the heart...


HEART FAILURE
  • METABOLISM
    • How do specific metabolic cues regulate cardiac structure and function? We are interested in cardiac muscle cells, vascular cells, and support cells (fibroblasts).
  • INFLAMMATION
    • How do leukocytes interact with the extracellular matrix during heart failure?
  • FIBROSIS
    • What biomechanics changes occur during heart failure and how are such changes regulated?
EXERCISE AND THE CARDIOVASCULAR SYSTEM
  • What are the structural consequences of physical activity on the heart?
  • How does physical activity alter cell function in the heart?
  • How can insights from physical activity be applied to the failing heart?
  • Can physical activity be used as an intervention in heart failure?
Other Areas of Interest
  • Heart-kidney interactions (cardiorenal syndrome)
  • Heart-liver interactions
  • Cardiovascular aging
  • Risk factors (such as diabetes) in the development of disease

Matricellular protein CCN1 promotes collagen alignment and scar integrity after myocardial infarction


A. G. Fischer, E. M. Elliott, K. R. Brittian, L. Garrett, G. Sadri, J. Aebersold, R. A. Singhal, Y. Nong, A. Leask, S. P. Jones, J. B. Moore Iv

Matrix Biol, vol. 133, 2024, pp. 14-32


Investigating the effects of long-term Aroclor 1260 exposure on fatty liver disease in a diet-induced obesity mouse model


Kimberly Z Head, Oluwanifemi E Bolatimi, Tyler C Gripshover, Min Tan, Yan Li, Timothy N Audam, Steven P Jones, Carolyn M Klinge, Matthew C Cave, Banrida Wahlang

Front Gastroenterol (Lausanne), vol. 2, 2023, p. 1180712


Influence of biological sex and exercise on murine cardiac metabolism


Kyle Fulghum, Helen E. Collins, Steven P. Jones, Bradford G. Hill

J Sport Health Sci, vol. 11(4), 2022, pp. 479–494


Metabolic signatures of pregnancy-induced cardiac growth


Kyle L. Fulghum, Juliette B. Smith, Julia Chariker, Lauren F. Garrett, Kenneth R. Brittian, Pawel K. Lorkiewicz, Lindsey A. McNally, Shizuka Uchida, Steven P. Jones, Bradford G. Hill, Helen E. Collins

Am J Physiol Heart Circ Physiol, vol. 323(1), 2022, pp. H146–H164


Collagen type XIX regulates cardiac extracellular matrix structure and ventricular function


Ghazal Sadri, Annalara G. Fischer, Kenneth R. Brittian, Erin Elliott, Matthew A. Nystoriak, Shizuka Uchida, Marcin Wysoczynski, Andrew Leask, Steven P. Jones, Joseph B. Moore

Matrix Biology, vol. 109, Elsevier {BV}, 2022 May, pp. 49--69


Guidelines for in vivo mouse models of myocardial infarction


Merry L Lindsey, Keith R Brunt, Jonathan A Kirk, Petra Kleinbongard, John W Calvert, Lisandra E de Castro Br{\'a}s, Kristine Y DeLeon-Pennell, Dominic P Del Re, Nikolaos G Frangogiannis, Stefan Frantz, Richard J Gumina, Ganesh V Halade, Steven P Jones, Rebecca H Ritchie, Francis G Spinale, Edward B Thorp, Crystal M Ripplinger, Zamaneh Kassiri

Am. J. Physiol. Heart Circ. Physiol., vol. 321, American Physiological Society, 2021 Dec, pp. H1056--H1073


Chronic benzene exposure aggravates pressure overload-induced cardiac dysfunction


Igor N Zelko, Sujith Dassanayaka, Marina V Malovichko, Caitlin M Howard, Lauren F Garrett, Shizuka Uchida, Kenneth R Brittian, Daniel J Conklin, Steven P Jones, Sanjay Srivastava

Toxicol. Sci., vol. 185, Oxford University Press (OUP), 2021 Dec, pp. 64--76


Cardiac PANK1 deletion exacerbates ventricular dysfunction during pressure overload


Timothy N Audam, Caitlin M Howard, Lauren F Garrett, Yi Wei Zheng, James A Bradley, Kenneth R Brittian, Matthew W Frank, Kyle L Fulghum, Mikl{\'o}s P{\'o}los, Szilvia Herczeg, B{\'e}la Merkely, Tam{\'a}s Radovits, Shizuka Uchida, Bradford G Hill, Sujith Dassanayaka, Suzanne Jackowski, Steven P Jones

Am. J. Physiol. Heart Circ. Physiol., vol. 321, American Physiological Society, 2021 Oct, pp. H784--H797


Angiotensinogen takes some of the spotlight from angiotensin II in the cardiohepatic axis


Steven P Jones

Circ. Res., vol. 129, 2021 Aug, pp. 565--567


The sweet smell of progress with hyaluronan and heart failure


Pilar Alcaide, Steven P Jones

Hypertension, vol. 77, Ovid Technologies (Wolters Kluwer Health), 2021 Jun, pp. 1928--1930


Cardiomyocyte Oga haploinsufficiency increases O-GlcNAcylation but hastens ventricular dysfunction following myocardial infarction


Sujith Dassanayaka, Kenneth R Brittian, Bethany W Long, Lauren A Higgins, James A Bradley, Timothy N Audam, Andrea Jurkovic, Anna M Gumpert, Linda T Harrison, Istv{\'a}n Harty{\'a}nszky, P{\'e}ter Perge, B{\'e}la Merkely, Tam{\'a}s Radovits, John A Hanover, Steven P Jones

PLoS One, vol. 15, Public Library of Science (PLoS), 2020 Nov, pp. e0242250


Cardiac mesenchymal cells from failing and nonfailing hearts limit ventricular dilation when administered late after infarction


Timothy N Audam, Yibing Nong, Alex Tomlin, Andrea Jurkovic, Hong Li, Xiaoping Zhu, Bethany W Long, Yi Wei Zheng, Tyler Weirick, Kenneth R Brittian, Daniel W Riggs, Anna Gumpert, Shizuka Uchida, Yiru Guo, Marcin Wysoczynski, Steven P Jones

Am. J. Physiol. Heart Circ. Physiol., vol. 319, American Physiological Society, 2020 Jul, pp. H109--H122


A new framework for performing cardiac strain analysis from cine MRI imaging in mice


K Hammouda, F Khalifa, H Abdeltawab, A Elnakib, G A Giridharan, M Zhu, C K Ng, S Dassanayaka, M Kong, H E Darwish, T M A Mohamed, S P Jones, A El-Baz

Sci. Rep., vol. 10, 2020 May, p. 7725


Metabolic regulation of Kv channels and cardiac repolarization by Kv$\beta$2 subunits


Peter J Kilfoil, Kalyan C Chapalamadugu, Xuemei Hu, Deqing Zhang, Frank J Raucci Jr, Jared Tur, Kenneth R Brittian, Steven P Jones, Aruni Bhatnagar, Srinivas M Tipparaju, Matthew A Nystoriak

J. Mol. Cell. Cardiol., vol. 137, Elsevier BV, 2019 Dec, pp. 93--106


Physiological biomimetic culture system for pig and human heart slices


Qinghui Ou, Zo{\"e} Jacobson, Riham R E Abouleisa, Xian-Liang Tang, Sajedah M Hindi, Ashok Kumar, Kathryn N Ivey, Guruprasad Giridharan, Ayman El-Baz, Kenneth Brittian, Benjamin Rood, Ying-Hsi Lin, Samuel A Watson, Filippo Perbellini, Timothy A McKinsey, Bradford G Hill, Steven P Jones, Cesare M Terracciano, Roberto Bolli, Tamer M A Mohamed

Circ. Res., vol. 125, Ovid Technologies (Wolters Kluwer Health), 2019 Aug, pp. 628--642


RDH10 function is necessary for spontaneous fetal mouth movement that facilitates palate shelf elevation


Regina M Friedl, Swetha Raja, Melissa A Metzler, Niti D Patel, Kenneth R Brittian, Steven P Jones, Lisa L Sandell

Dis. Model. Mech., vol. 12, The Company of Biologists, 2019 Jul, pp. dmm039073


E2f1 deletion attenuates infarct-induced ventricular remodeling without affecting O-GlcNAcylation


Sujith Dassanayaka, Kenneth R Brittian, Andrea Jurkovic, Lauren A Higgins, Timothy N Audam, Bethany W Long, Linda T Harrison, Giuseppe Militello, Daniel W Riggs, Mitali G Chitre, Shizuka Uchida, Senthilkumar Muthusamy, Anna M Gumpert, Steven P Jones

Basic Res. Cardiol., vol. 114, Springer Science and Business Media LLC, 2019 May, p. 28


Cardiac-specific overexpression of aldehyde dehydrogenase 2 exacerbates cardiac remodeling in response to pressure overload


Sujith Dassanayaka, Yuting Zheng, Andrew A Gibb, Timothy D Cummins, Lindsey A McNally, Kenneth R Brittian, Ganapathy Jagatheesan, Timothy N Audam, Bethany W Long, Robert E Brainard, Steven P Jones, Bradford G Hill

Redox Biol., vol. 17, 2018 Jul, pp. 440--449


Deficiency of aldose reductase exacerbates early pressure overload-induced cardiac dysfunction and autophagy in mice


Shahid P Baba, Deqing Zhang, Mahavir Singh, Sujith Dassanayaka, Zhengzhi Xie, Ganapathy Jagatheesan, Jingjing Zhao, Virginia K Schmidtke, Kenneth R Brittian, Michael L Merchant, Daniel J Conklin, Steven P Jones, Aruni Bhatnagar

J. Mol. Cell. Cardiol., vol. 118, 2018 May, pp. 183--192


Airn regulates Igf2bp2 translation in cardiomyocytes


Mohammed Rabiul Hosen, Giuseppe Militello, Tyler Weirick, Yuliya Ponomareva, Sujith Dassanayaka, Joseph B Moore 4th, Claudia D{\"o}ring, Marcin Wysoczynski, Steven P Jones, Stefanie Dimmeler, Shizuka Uchida

Circ. Res., vol. 122, Ovid Technologies (Wolters Kluwer Health), 2018 May, pp. 1347--1353


Guidelines for experimental models of myocardial ischemia and infarction


Merry L Lindsey, Roberto Bolli, John M Canty Jr, Xiao-Jun Du, Nikolaos G Frangogiannis, Stefan Frantz, Robert G Gourdie, Jeffrey W Holmes, Steven P Jones, Robert A Kloner, David J Lefer, Ronglih Liao, Elizabeth Murphy, Peipei Ping, Karin Przyklenk, Fabio A Recchia, Lisa Schwartz Longacre, Crystal M Ripplinger, Jennifer E Van Eyk, Gerd Heusch

Am. J. Physiol. Heart Circ. Physiol., vol. 314, 2018 Apr, pp. H812--H838


RNA editing: Unexplored opportunities in the cardiovascular system


Shizuka Uchida, Steven P Jones

Circ. Res., vol. 122, 2018 Feb, pp. 399--401


Exercise-induced changes in glucose metabolism promote physiological cardiac growth


Andrew A Gibb, Paul N Epstein, Shizuka Uchida, Yuting Zheng, Lindsey A McNally, Detlef Obal, Kartik Katragadda, Patrick Trainor, Daniel J Conklin, Kenneth R Brittian, Michael T Tseng, Jianxun Wang, Steven P Jones, Aruni Bhatnagar, Bradford G Hill

Circulation, vol. 136, Ovid Technologies (Wolters Kluwer Health), 2017 Nov, pp. 2144--2157


Integration of flux measurements to resolve changes in anabolic and catabolic metabolism in cardiac myocytes


Andrew A Gibb, Pawel K Lorkiewicz, Yu-Ting Zheng, Xiang Zhang, Aruni Bhatnagar, Steven P Jones, Bradford G Hill

Biochem. J., vol. 474, 2017 Aug, pp. 2785--2801


Why publish in the American Journal of Physiology-Heart and Circulatory Physiology?


Irving H Zucker, Merry L Lindsey, Mario Delmar, Leon J De Windt, Christine Des Rosiers, Debra I Diz, Robert L Hester, Steven P Jones, Nancy L Kanagy, Masafumi Kitakaze, Ronglih Liao, Gary D Lopaschuk, Kaushik P Patel, Fabio A Recchia, Junichi Sadoshima, Ajay M Shah, Zoltan Ungvari, Ivor J Benjamin, Mordecai P Blaustein, Nisha Charkoudian, Igor R Efimov, David Gutterman, David A Kass, Yulin Liao, Donal S O'Leary, Crystal M Ripplinger, Michael S Wolin

Am. J. Physiol. Heart Circ. Physiol., vol. 313, 2017 Aug, pp. H221--H223


I'll have the rigor, but hold the mortis


Steven P Jones

Circ. Res., vol. 120, 2017 Jun, pp. 1852--1854


Cardiomyocyte Ogt limits ventricular dysfunction in mice following pressure overload without affecting hypertrophy


Sujith Dassanayaka, Robert E Brainard, Lewis J Watson, Bethany W Long, Kenneth R Brittian, Angelica M DeMartino, Allison L Aird, Anna M Gumpert, Timothy N Audam, Peter J Kilfoil, Senthilkumar Muthusamy, Tariq Hamid, Sumanth D Prabhu, Steven P Jones

Basic Res. Cardiol., vol. 112, 2017 May, p. 23


Leukocyte iNOS is required for inflammation and pathological remodeling in ischemic heart failure


Justin R Kingery, Tariq Hamid, Robert K Lewis, Mohamed Ameen Ismahil, Shyam S Bansal, Gregg Rokosh, Tim M Townes, Suzanne T Ildstad, Steven P Jones, Sumanth D Prabhu

Basic Res. Cardiol., vol. 112, 2017 Mar, p. 19


TNF receptor signaling inhibits cardiomyogenic differentiation of cardiac stem cells and promotes a neuroadrenergic-like fate


Tariq Hamid, Yuanyuan Xu, Mohamed Ameen Ismahil, Qianhong Li, Steven P Jones, Aruni Bhatnagar, Roberto Bolli, Sumanth D Prabhu

Am. J. Physiol. Heart Circ. Physiol., vol. 311, 2016 Nov, pp. H1189--H1201


A new method to stabilize C-kit expression in reparative cardiac mesenchymal cells


Marcin Wysoczynski, Sujith Dassanayaka, Ayesha Zafir, Shahab Ghafghazi, Bethany W Long, Camille Noble, Angelica M DeMartino, Kenneth R Brittian, Roberto Bolli, Steven P Jones

Front. Cell Dev. Biol., vol. 4, Frontiers Media SA, 2016 Aug, p. 78


E2F1 transcription factor regulates O-linked N-acetylglucosamine (O-GlcNAc) transferase and O-GlcNAcase expression


Senthilkumar Muthusamy, Kyung U Hong, Sujith Dassanayaka, Tariq Hamid, Steven P Jones

J. Biol. Chem., vol. 290, Elsevier BV, 2015 Dec, pp. 31013--31024


O-GlcNAcylation negatively regulates cardiomyogenic fate in adult mouse cardiac mesenchymal stromal cells


Ayesha Zafir, James A Bradley, Bethany W Long, Senthilkumar Muthusamy, Qianhong Li, Bradford G Hill, Marcin Wysoczynski, Sumanth D Prabhu, Aruni Bhatnagar, Roberto Bolli, Steven P Jones

PLoS One, vol. 10, Public Library of Science (PLoS), 2015 Nov, pp. e0142939


Induction of activating transcription factor 3 limits survival following infarct-induced heart failure in mice


Alan C Brooks, Angelica M DeMartino, Robert E Brainard, Kenneth R Brittian, Aruni Bhatnagar, Steven P Jones

Am. J. Physiol. Heart Circ. Physiol., vol. 309, American Physiological Society, 2015 Oct, pp. H1326--35


Recent developments in heart failure


Sujith Dassanayaka, Steven P Jones

Circ. Res., vol. 117, Ovid Technologies (Wolters Kluwer Health), 2015 Sep, pp. e58--63


High glucose induces mitochondrial dysfunction independently of protein O-GlcNAcylation


Sujith Dassanayaka, Ryan D Readnower, Joshua K Salabei, Bethany W Long, Allison L Aird, Yu-Ting Zheng, Senthilkumar Muthusamy, Heberty T Facundo, Bradford G Hill, Steven P Jones

Biochem. J., vol. 467, Portland Press Ltd., 2015 Apr, pp. 115--126


The NHLBI-sponsored Consortium for preclinicAl assESsment of cARdioprotective therapies (CAESAR): a new paradigm for rigorous, accurate, and reproducible evaluation of putative infarct-sparing interventions in mice, rabbits, and pigs


Steven P Jones, Xian-Liang Tang, Yiru Guo, Charles Steenbergen, David J Lefer, Rakesh C Kukreja, Maiying Kong, Qianhong Li, Shashi Bhushan, Xiaoping Zhu, Junjie Du, Yibing Nong, Heather L Stowers, Kazuhisa Kondo, Gregory N Hunt, Traci T Goodchild, Adam Orr, Carlos C Chang, Ramzi Ockaili, Fadi N Salloum, Roberto Bolli

Circ. Res., vol. 116, 2015 Feb, pp. 572--586


MicroRNA-539 is up-regulated in failing heart, and suppresses O-GlcNAcase expression


Senthilkumar Muthusamy, Angelica M DeMartino, Lewis J Watson, Kenneth R Brittian, Ayesha Zafir, Sujith Dassanayaka, Kyung U Hong, Steven P Jones

J. Biol. Chem., vol. 289, Elsevier BV, 2014 Oct, pp. 29665--29676


Endothelial dysfunction as a nexus for endothelial cell-cardiomyocyte miscommunication


Thorsten M Leucker, Steven P Jones

Front. Physiol., vol. 5, Frontiers Media SA, 2014 Aug, p. 328


Metabolomic analysis of pressure-overloaded and infarcted mouse hearts


Brian E Sansbury, Angelica M DeMartino, Zhengzhi Xie, Alan C Brooks, Robert E Brainard, Lewis J Watson, Andrew P DeFilippis, Timothy D Cummins, Matthew A Harbeson, Kenneth R Brittian, Sumanth D Prabhu, Aruni Bhatnagar, Steven P Jones, Bradford G Hill

Circ. Heart Fail., vol. 7, Ovid Technologies (Wolters Kluwer Health), 2014 Jul, pp. 634--642


O-GlcNAc and the cardiovascular system


Sujith Dassanayaka, Steven P Jones

Pharmacol. Ther., vol. 142, Elsevier BV, 2014 Apr, pp. 62--71


Cardiomyocyte Ogt is essential for postnatal viability


Lewis J Watson, Bethany W Long, Angelica M DeMartino, Kenneth R Brittian, Ryan D Readnower, Robert E Brainard, Timothy D Cummins, Lakshmanan Annamalai, Bradford G Hill, Steven P Jones

Am. J. Physiol. Heart Circ. Physiol., vol. 306, American Physiological Society, 2014 Jan, pp. H142--53


High fat feeding in mice is insufficient to induce cardiac dysfunction and does not exacerbate heart failure


Robert E Brainard, Lewis J Watson, Angelica M Demartino, Kenneth R Brittian, Ryan D Readnower, Adjoa Agyemang Boakye, Deqing Zhang, Joseph David Hoetker, Aruni Bhatnagar, Shahid Pervez Baba, Steven P Jones

PLoS One, vol. 8, Public Library of Science (PLoS), 2013 Dec, pp. e83174


PDGF-mediated autophagy regulates vascular smooth muscle cell phenotype and resistance to oxidative stress


Joshua K Salabei, Timothy D Cummins, Mahavir Singh, Steven P Jones, Aruni Bhatnagar, Bradford G Hill

Biochem. J., vol. 451, Portland Press Ltd., 2013 May, pp. 375--388


Protein O-GlcNAcylation is a novel cytoprotective signal in cardiac stem cells


Ayesha Zafir, Ryan Readnower, Bethany W Long, James McCracken, Allison Aird, Alejandro Alvarez, Timothy D Cummins, Qianhong Li, Bradford G Hill, Aruni Bhatnagar, Sumanth D Prabhu, Roberto Bolli, Steven P Jones

Stem Cells, vol. 31, Oxford University Press (OUP), 2013 Apr, pp. 765--775


Reduced cardiac fructose 2,6 bisphosphate increases hypertrophy and decreases glycolysis following aortic constriction


Jianxun Wang, Jianxiang Xu, Qianwen Wang, Robert E Brainard, Lewis J Watson, Steven P Jones, Paul N Epstein

PLoS One, vol. 8, Public Library of Science (PLoS), 2013 Jan, pp. e53951


Standardized bioenergetic profiling of adult mouse cardiomyocytes


Ryan D Readnower, Robert E Brainard, Bradford G Hill, Steven P Jones

Physiol. Genomics, vol. 44, American Physiological Society, 2012 Dec, pp. 1208--1213


The COX-2/PGI2 receptor axis plays an obligatory role in mediating the cardioprotection conferred by the late phase of ischemic preconditioning


Yiru Guo, Deepali Nivas Tukaye, Wen-Jian Wu, Xiaoping Zhu, Michael Book, Wei Tan, Steven P Jones, Gregg Rokosh, Shuh Narumiya, Qianhong Li, Roberto Bolli

PLoS One, vol. 7, Public Library of Science (PLoS), 2012 Jul, pp. e41178


O-GlcNAc signaling is essential for NFAT-mediated transcriptional reprogramming during cardiomyocyte hypertrophy


Heberty T Facundo, Robert E Brainard, Lewis J Watson, Gladys A Ngoh, Tariq Hamid, Sumanth D Prabhu, Steven P Jones

Am. J. Physiol. Heart Circ. Physiol., vol. 302, American Physiological Society, 2012 May, pp. H2122--30


Cardiac overexpression of 8-oxoguanine DNA glycosylase 1 protects mitochondrial DNA and reduces cardiac fibrosis following transaortic constriction


Jianxun Wang, Qianwen Wang, Lewis J Watson, Steven P Jones, Paul N Epstein

Am. J. Physiol. Heart Circ. Physiol., vol. 301, American Physiological Society, 2011 Nov, pp. H2073--80


Bioenergetic function in cardiovascular cells: the importance of the reserve capacity and its biological regulation


Brian E Sansbury, Steven P Jones, Daniel W Riggs, Victor M Darley-Usmar, Bradford G Hill

Chem. Biol. Interact., vol. 191, Elsevier BV, 2011 May, pp. 288--295


Responses of hypertrophied myocytes to reactive species: implications for glycolysis and electrophile metabolism


Brian E Sansbury, Daniel W Riggs, Robert E Brainard, Joshua K Salabei, Steven P Jones, Bradford G Hill

Biochem. J., vol. 435, Portland Press Ltd., 2011 Apr, pp. 519--528


Augmented O-GlcNAc signaling attenuates oxidative stress and calcium overload in cardiomyocytes


Gladys A Ngoh, Lewis J Watson, Heberty T Facundo, Steven P Jones

Amino Acids, vol. 40, Springer Science and Business Media LLC, 2011 Mar, pp. 895--911


O-linked $\beta$-N-acetylglucosamine transferase is indispensable in the failing heart


Lewis J Watson, Heberty T Facundo, Gladys A Ngoh, Mohamed Ameen, Robert E Brainard, Kewakebt M Lemma, Bethany W Long, Sumanth D Prabhu, Yu-Ting Xuan, Steven P Jones

Proc. Natl. Acad. Sci. U. S. A., vol. 107, Proceedings of the National Academy of Sciences, 2010 Oct, pp. 17797--17802


O-GlcNAc signaling in the cardiovascular system


Gladys A Ngoh, Heberty T Facundo, Ayesha Zafir, Steven P Jones

Circ. Res., vol. 107, Ovid Technologies (Wolters Kluwer Health), 2010 Jul, pp. 171–185


Unique hexosaminidase reduces metabolic survival signal and sensitizes cardiac myocytes to hypoxia/reoxygenation injury


Gladys A Ngoh, Heberty T Facundo, Tariq Hamid, Wolfgang Dillmann, Natasha E Zachara, Steven P Jones

Circ Res, vol. 104(1), 2009, pp. 41–49


O-GlcNAc signaling attenuates ER stress-induced cardiomyocyte death


Gladys A Ngoh, Tariq Hamid, Sumanth D Prabhu, Steven P Jones

Am. J. Physiol. Heart Circ. Physiol., vol. 297, American Physiological Society, 2009 Nov, pp. H1711–9


Non-canonical glycosyltransferase modulates post-hypoxic cardiac myocyte death and mitochondrial permeability transition


Gladys A Ngoh, Lewis J Watson, Heberty T Facundo, Wolfgang Dillmann, Steven P Jones

J Mol Cell Cardiol, vol. 45(2), 2008, pp. 313–325


New insights into metabolic signaling and cell survival: the role of beta-O-linkage of N-acetylglucosamine


Gladys A Ngoh, Steven P Jones

J Pharmacol Exp Ther., vol. 327(3), 2008, pp. 602–609


Cardiac phosphatase-deficient 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase increases glycolysis, hypertrophy, and myocyte resistance to hypoxia


Qianwen Wang, Rajakumar V Donthi, Jianxun Wang, Alex J Lange, Lewis J Watson, Steven P Jones, Paul N Epstein

Am J Physiol Heart Circ Physiol, vol. 294(6), 2008, pp. H2889–97


Cardioprotection by N-acetylglucosamine linkage to cellular proteins


Steven P Jones, Natasha E Zachara, Gladys A Ngoh, Bradford G Hill, Yasushi Teshima, Aruni Bhatnagar, Gerald W Hart, Eduardo Marbán

Circulation, vol. 117(9), 2008, pp. 1172–1182


Low-dose simvastatin improves survival and ventricular function via eNOS in congestive heart failure


James J M Greer, Aman K Kakkar, John W Elrod, Lewis J Watson, Steven P Jones, David J Lefer

Am J Physiol Heart Circ Physiol, vol. 291(6), 2006, pp. H2743–51


The ubiquitous role of nitric oxide in cardioprotection


Steven P Jones, Roberto Bolli

J Mol Cell Cardiol, vol. 40(1), 2006, pp. 16–23


Deficiency of iNOS does not attenuate severe congestive heart failure in mice


Steven P Jones, James J M Greer, Paul D Ware, Jiang Yang, Kenneth Walsh, David J Lefer

Am J Physiol Heart Circ Physiol, vol. 288(1), 2005, pp. H365–70


Functional integration of electrically active cardiac derivatives from genetically engineered human embryonic stem cells with quiescent recipient ventricular cardiomyocytes: insights into the development of cell-based pacemakers


Tian Xue, Hee Cheol Cho, Fadi G Akar, Suk-Ying Tsang, Steven P Jones, Eduardo Marbán, Gordon F Tomaselli, Ronald A Li

Circulation, vol. 111(1), 2005, pp. 11–20


Endothelial nitric oxide synthase overexpression attenuates myocardial reperfusion injury


Steven P Jones, James J M Greer, Aman K Kakkar, P Derek Ware, Richard H Turnage, Michael Hicks, Rien van Haperen, Rini de Crom, Seinosuke Kawashima, Mitsuhiro Yokoyama, David J Lefer

Am J Physiol Heart Circ Physiol, vol. 286(1), 2004, pp. H276–82


Differential actions of cardioprotective agents on the mitochondrial death pathway


Masaharu Akao, Brian O'Rourke, Hideo Kusuoka, Yasushi Teshima, Steven P Jones, Eduardo Marbán

Circ Res, vol. 92(2), 2003, pp. 195–202


Endothelial nitric oxide synthase overexpression attenuates congestive heart failure in mice


Steven P Jones, James J M Greer, Rien van Haperen, Dirk J Duncker, Rini de Crom, David J Lefer

Proc Natl Acad Sci USA, vol. 100(8), 2003, pp. 4891–6


Role of intracellular antioxidant enzymes after in vivo myocardial ischemia and reperfusion


Steven P Jones, Michaela R Hoffmeyer, Brent R Sharp, Ye-Shih Ho, David J Lefer

Am J Physiol Heart Circ Physiol, vol. 284(1), 2003, pp. H277–82


Simvastatin attenuates oxidant-induced mitochondrial dysfunction in cardiac myocytes


Steven P Jones, Yasushi Teshima, Masaharu Akao, Eduardo Marbán

Circ Res, vol. 93(8), 2003, pp. 697–699


Uncoupling protein-2 overexpression inhibits mitochondrial death pathway in cardiomyocytes


Yasushi Teshima, Masaharu Akao, Steven P Jones, Eduardo Marbán

Circ Res, vol. 93(3), 2003, pp. 192–200


Cariporide (HOE642), a selective Na+-H+ exchange inhibitor, inhibits the mitochondrial death pathway


Yasushi Teshima, Masaharu Akao, Steven P Jones, Eduardo Marbán

Circulation, vol. 108(18), 2003, pp. 2275–2281


Differential response to myocardial reperfusion injury in eNOS-deficient mice


Brent R Sharp, Steven P Jones, David M Rimmer, David J Lefer

Am J Physiol Heart Circ Physiol, vol. 282(6), 2002, pp. H2422–6


Direct vascular and cardioprotective effects of rosuvastatin, a new HMG-CoA reductase inhibitor


Steven P Jones, Michael F Gibson, David M Rimmer 3rd, Terrie M Gibson, Brent R Sharp, David J Lefer

J Am Coll Cardiol, vol. 40(6), 2002, pp. 1172–8


HMG-CoA reductase inhibition protects the diabetic myocardium from ischemia-reperfusion injury


D J Lefer, R Scalia, S P Jones, B R Sharp, M R Hoffmeyer, A R Farvid, M F Gibson, A M Lefer

FASEB J, vol. 15(8), 2001, pp. 1454–6


Heart-targeted overexpression of caspase3 in mice increases infarct size and depresses cardiac function


G Condorelli, R Roncarati, J Ross Jr, A Pisani, G Stassi, M Todaro, S Trocha, A Drusco, Y Gu, M A Russo, G Frati, S P Jones, D J Lefer, C Napoli, C M Croce

Proc Natl Acad Sci USA, vol. 98(17), 2001, pp. 9977–82


Simvastatin exerts both anti-inflammatory and cardioprotective effects in apolipoprotein E-deficient mice


R Scalia, M E Gooszen, S P Jones, M Hoffmeyer, D M Rimmer 3rd, S D Trocha, P L Huang, M B Smith, A M Lefer, D J Lefer

Circulation, vol. 103(21), 2001, pp. 2598–603


Acute exposure to a high cholesterol diet attenuates myocardial ischemia-reperfusion injury in cholesteryl ester transfer protein mice


S P Jones, W G Girod, K R Marotti, T Y Aw, D J Lefer

Coron Artery Dis, vol. 12(1), 2001, pp. 37–44


Cardioprotective actions of acute HMG-CoA reductase inhibition in the setting of myocardial infarction


Steven P Jones, David J Lefer

Acta Physiol Scand, vol. 173(1), 2001, pp. 139–143


Pretreatment with simvastatin attenuates myocardial dysfunction after ischemia and chronic reperfusion


Steven P Jones, Stephen D Trocha, David J Lefer

Arterioscler Thromb Vasc Biol, vol. 21(12), 2001, pp. 2059–64


Cardioprotective actions of endogenous IL-10 are independent of iNOS


Steven P Jones, Stephen D Trocha, David J Lefer

Am J Physiol Heart Circ Physiol, vol. 281(1), 2001, pp. H48–52


CD8(+)-T-cell depletion ameliorates circulatory shock in Plasmodium berghei-infected mice


W L Chang, S P Jones, D J Lefer, T Welbourne, G Sun, L Yin, H Suzuki, J Huang, D N Granger, H C van der Heyde

Infect Immun, vol. 69(12), 2001, pp. 7341–8


PR-39, a potent neutrophil inhibitor, attenuates myocardial ischemia-reperfusion injury in mice


M R Hoffmeyer, R Scalia, C R Ross, S P Jones, D J Lefer

Am J Physiol Heart Circ Physiol, vol. 279(6), 2000, pp. H2824–8


Myocardial ischemia/reperfusion injury in NADPH oxidase-deficient mice


M R Hoffmeyer, S P Jones, C R Ross, B Sharp, M B Grisham, F S Laroux, T J Stalker, R Scalia, D J Lefer

Circ Res, vol. 87(9), 2000, pp. 812–7


The MEK1-ERK1/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic mice


O F Bueno, L J De Windt, K M Tymitz, S A Witt, T R Kimball, R Klevitsky, T E Hewett, S P Jones, D J Lefer, C F Peng, R N Kitsis, J D Molkentin

EMBO J, vol. 19(23), 2000, pp. 6341–50


Leukocyte and endothelial cell adhesion molecules in a chronic murine model of myocardial reperfusion injury


S P Jones, S D Trocha, M B Strange, D N Granger, C G Kevil, D C Bullard, D J Lefer

Am J Physiol Heart Circ Physiol, vol. 279(5), 2000, pp. H2196–201


Myocardial reperfusion injury in neuronal nitric oxide synthase deficient mice


S P Jones, W G Girod, P L Huang, D J Lefer

Coron Artery Dis, vol. 11(8), 2000, pp. 593–7


Myocardial Reperfusion Injury: Insights Gained from Gene-Targeted Mice


Steven P Jones, David J Lefer

News Physiol Sci, vol. 15, 2000, pp. 303–308


Using gene-targeted mice to investigate the pathophysiology of myocardial reperfusion injury


Steven P Jones, David J Lefer

Basic Res Cardiol, vol. 95(6), 2000, pp. 499–502


Leukocyte-endothelial cell interactions in nitric oxide synthase-deficient mice


D J Lefer, S P Jones, W G Girod, A Baines, M B Grisham, A S Cockrell, P L Huang, R Scalia

Am J Physiol, vol. 276(6), 1999, pp. H1943–50


Myocardial ischemia-reperfusion injury is exacerbated in absence of endothelial cell nitric oxide synthase


S P Jones, W G Girod, A J Palazzo, D N Granger, M B Grisham, D Jourd'Heuil, P L Huang, D J Lefer

Am J Physiol, vol. 276(5), 1999, pp. H1567–73


Effects of hypercholesterolemia on myocardial ischemia-reperfusion injury in LDL receptor-deficient mice


W G Girod, S P Jones, N Sieber, T Y Aw, D J Lefer

Arterioscler Thromb Vasc Biol, vol. 19(11), 1999, pp. 2779–81


Coronary endothelial P-selectin in pathogenesis of myocardial ischemia-reperfusion injury


A J Palazzo, S P Jones, D C Anderson, D N Granger, D J Lefer

Am J Physiol, vol. 275(5), 1998, pp. H1865–72


Myocardial ischemia-reperfusion injury in CD18- and ICAM-1-deficient mice


A J Palazzo, S P Jones, W G Girod, D C Anderson, D N Granger, D J Lefer

Am J Physiol, vol. 275(6), 1998, pp. H2300–7

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