The Jones Laboratory
Defining how metabolism and the extracellular matrix shape cardiac inflammation and remodeling.
We investigate how metabolic cues and extracellular matrix-derived signals regulate:
- Inflammation and metabolism
- Ventricular remodeling
- Functional adaptation in cardiometabolic disease
Our work integrates rigorous cardiovascular physiology with immunometabolism and matrix biology to define mechanisms that drive heart failure—and identify pathways with translational relevance.
NIH- and AHA-supported discovery.
Reproducible experimental platforms.
Mechanistic depth with physiological relevance.
NIH- and AHA-supported discovery.
Reproducible experimental platforms.
Mechanistic depth with physiological relevance.
Mechanistic Focus
Metabolic Control of Remodeling
Nutrient- and stress-responsive pathways shape cardiomyocyte and immune cell behavior during pressure overload, ischemia, and metabolic disease.
Nutrient- and stress-responsive pathways shape cardiomyocyte and immune cell behavior during pressure overload, ischemia, and metabolic disease.
Matrix–Immune Crosstalk
Extracellular matrix components, such as hyaluronan, function as dynamic signaling platforms regulating inflammation, fibrosis, and ventricular adaptation.
Extracellular matrix components, such as hyaluronan, function as dynamic signaling platforms regulating inflammation, fibrosis, and ventricular adaptation.
Integrative Physiology
In vivo models and advanced phenotyping ensure discoveries are grounded in function, not just association.
In vivo models and advanced phenotyping ensure discoveries are grounded in function, not just association.
Reproducible Translational Science
Methodological leadership emphasizing rigor, scalability, and reproducibility across preclinical models.
Methodological leadership emphasizing rigor, scalability, and reproducibility across preclinical models.
How We Interrogate Biology
We deploy complementary genetic, pharmacological, and physiological strategies to interrogate cardiometabolic disease mechanisms across scales:
- Molecular signaling
- Cellular adaptation
- Whole-organ function
Our studies span heart failure, metabolic stress, ischemic injury, and cardiorenal interactions—emphasizing pathways that integrate metabolism, inflammation, and matrix remodeling.
Collaborative and interdisciplinary by design.
Collaborative and interdisciplinary by design.
Training Rigorous Scientists
A core mission of the Jones Laboratory is to train the next generation of cardiovascular investigators.
Our trainees:
Our trainees:
- Earn NIH and AHA fellowships
- Publish high-impact mechanistic studies
- Advance to successful academic and industry careers
We emphasize independence, causal thinking, experimental precision, and conceptual creativity.
Explore
- Research Programs – Current projects and scientific themes
- Publications – Selected and recent work from the laboratory
- People – Current staff and trainees; trainee alumni
- Resources & Cores – Infrastructure supporting rigorous cardiovascular research
- Join Us – Opportunities for trainees and collaborators
Publications
For a complete list, please visit our Publications Page.