Heart failure doesn't always announce itself with a single catastrophic event—it accumulates, driven by metabolic dysfunction, matrix remodeling, and inflammation that the field still doesn't fully understand. The Jones Laboratory works on that problem.

NIH- and AHA-supported. Reproducible experimental platforms. Mechanistic depth with physiological stakes.

Mechanistic Focus

How We Interrogate Biology

We work across molecular, cellular, and whole-organ scales—in heart failure, ischemic injury, metabolic disease, exercise, and cardiorenal contexts—with an emphasis on causal mechanisms and collaborative, interdisciplinary design.

Training Rigorous Scientists

Training is not a secondary function of this laboratory—it is part of the scientific mission. The best mechanistic work requires scientists who can think independently, design experiments that distinguish cause from correlation, and pursue questions that matter beyond their own dissertation.

All prior PhD students in the Jones Laboratory earned NIH or AHA fellowships, published mechanistic work in strong journals, and went on to independent academic positions and research careers in industry. More importantly, they leave with the habits of mind that make a scientific career durable: rigor, intellectual honesty, and the ability to generate new questions from their own data.

If you are a prospective graduate student or postdoctoral fellow interested in cardiovascular mechanisms, see the people who have trained here—and reach out.

Explore

• Research Programs – Current projects and scientific themes
• Publications – Selected and recent work from the laboratory
• People – Current staff and trainees; trainee alumni
• Resources & Cores – Infrastructure supporting rigorous cardiovascular research
• Join Us – Graduate positions and undergraduate opportunities; collaborative inquiries welcome